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KMID : 0380620220540030297
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 3 p.297 ~ p.305
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Anti-obesity effect of radish leaf extracts on high fat diet-induced obesity in mice
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Lee Yun-Seong
Seo Young-Ho
Kim Ji-Yong
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Abstract
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The goal of this study was to evaluate the anti-obesity effect of radish leaf extracts (MU-C) and radish leaf extracts with 3% citric acid (MU-CA) in a high-fat diet (HFD)-induced C57BL/6 mice. The effects of radish leaf extracts on adipogenesis were also investigated using 3T3-L1 adipocytes. As determined by Oil red O staining, MU-C inhibited adipogenesis in 3T3-L1 adipocytes. Four-week-old male C57BL/6 mice were fed an HFD for 6 weeks and then treated with radish leaf extracts (500 mg/kg, p.o.) for 6 weeks. Then, the serum levels of Aspartate aminotransferase, Alanine aminotransferase, Total cholesterol, Triglyceride and low-density lipoprotein cholesterol in the mice were measured using an automatic chemical analyzer and enzyme-linked immunosorbent assay. Administration of MU-C significantly reduced the fat weight when compared with HFD controls. As confirmed by histopathologic analysis, adipose tissue size markedly decreased in mice treated with MU-C. Therefore, this study could provide a basis for investigating the clinical use of MUC as an agent for preventing obesity.
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KEYWORD
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radish leaf extract, anti-obesity, blood lipid, adipocytes, high fat diet
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